加国头条 i4cc.ca ｜博士后招聘启事，来自浙江大学医学院马骏教授组和迈阿密大学刘学忠教授组

▎学术经纬/报道

浙江大学遗传学研究所以建设国际一流的、开放的研究所为目标，致力于遗传学基础和应用的原创性研究。马骏教授于2017年全职加盟浙江大学遗传学研究所，建立了全新的系统发育生物学实验室，现面向国内外公开招聘高水平博士后2-3名，热忱欢迎相关背景的优秀青年学者加盟！

一、实验室简介

实验室PI：

马骏，浙江大学遗传学研究所教授、浙江大学医学院附属儿童医院兼聘教授、博士生导师、国家创新人才入选者。长期致力于基因表达调控和胚胎发育的研究，在Cell、Nature、Nature Cell Biology和Nature Communications等国际顶尖学术杂志上发表论文60余篇，其中1篇被Cell在2004年评为其30年出版史上最有影响力的25篇论文之一；现任国际著名刊物Molecular Systems Biology、eLife、PLOS Computational Biology和Development等特邀评审专家。

个人主页：http://person.zju.edu.cn/jun_ma_lab_cn。

实验室研究方向：

本实验室旨在探索多样化的细胞和生命系统所具有的一般性规律。当前主要研究方向：以生命物质及能量作为有限资源为出发点，设计系统的实验和分析流程，探索细胞和发育进程所遵循的、根本性的调控逻辑和方式。主要课题包括：

结合生化实验技术和定量生物学方法，研究F-box蛋白和Torso/MAPK通路在果蝇胚胎前后端发育中的调控作用；
结合核糖体展示和高通量测序技术，研究果蝇母体基因mRNA的翻译调控，并系统阐释其对胚胎早期模式发育的作用；
探索母体生殖细胞中营养物质的感受和分配对胚胎的产生与质量的影响；
构建细胞和在体的荧光报告基因系统，以监测和定量分析能量代谢相关的酶和重要调控因子；
建立以ChIP-seq等技术为基础的实验流程，研究生物资源分配（bio-resource allocation）策略对细胞进程和发育模式的影响；
通过数学模型和计算机模拟分析和预测在不同系统中生物资源分配策略的作用。

二、职位要求

在国内外知名高校及研究机构取得博士学位，年龄35周岁以下（外籍人员不超过40周岁），身体健康，富有责任心和协作精神；
具有较好的创造性科研思维并能够独立完成工作；
有本实验室研究方向相关的技术背景者，优先考虑。

三、岗位待遇

1、提供具有竞争力的薪酬待遇，年薪20万元起（根据申请人条件浮动）；

2、享受浙江大学博士后相关福利待遇；

3、支持申报博士后基金以及其他国家与地方的科技项目；

4、提供专业的科研指导和一流的科研环境；

5、成绩优异的博士后，出站后全力推荐其申报浙江大学高级技术职务资格或其它相关工作。

四、应聘材料

详细的中英文简历（包括一般情况、受教育经历、工作经历、承担和参与的课题、代表性文章、所获奖励、两位本领域推荐专家的联系方式等）；
简述个人研究兴趣及受聘后的工作设想和目标。

五、联系方式

有意者请将应聘材料电子版发送至马骏教授/何峰副教授邮箱，主题注明“马骏课题组博士后应聘”。

联系人：马骏教授邮箱：jun_ma@zju.edu.cn

联系人：何峰副教授邮箱：feng_he@zju.edu.cn

Postdoctoral Associate - Genetic Deafness Research - University of Miami

点击“阅读原文”/“Read More”，即可访问原始招聘页面，并投递简历。

Job Description

A postdoctoral position supervised by Dr. Xuezhong Liu and his Co-investigator team at the University of Miami Miller School of Medicine, is available to work on the application of gene-/cell-/drug-based approaches to treat genetic deafness including Neurofibromatosis type II (NF2).

We are looking for outstanding scientists with laboratory experience holding a PhD, MD or equivalent degree in the fields of genetics, functional genomics, molecular biology, stem cell biology or related disciplines to join our laboratory as part of a project to identify genetic factors linked to deafness and develop therapeutic strategies for the treatment of hearing loss. These positions offers an unique and exciting opportunity to work as part of a multidisciplinary and collaborative team engaged in developing cutting-edge technologies to study deafness and inner ear development with direct application for treating hearing loss in humans. We have identified multiple new deafness genes in humans and are developing animal models and induced pluripotent stem cell (iPSC) lines to study the role that these genes play in the development of hearing loss.

We are particularly interested in advancing novel biological approaches such as CRISPR-based gene therapy to treat hearing loss in genetic diseases in the following areas:

1) Development of genome editing or AAV based gene therapy to rescue hearing in the mouse models of human hearing loss;

2) Advance the study of using CRISPR to correct disease phenotype using iPS cells from human deafness patients;

3) preclinical studies in screening and testing the effectiveness of already FDA-approved drugs on mouse and human deafness gene-deficient cell lines and in animal models of human deafness;

4) Development of new delivery route for application of CRISPR in other inner ear cell types (supporting cells, stria vascularis and ganglion neurons) to treat hearing loss with different cellular origins.

Candidates should be independent and highly motivated with strong communication and critical thinking skills, as well as a dedication to teamwork and collaboration. Candidates will utilize animal models, iPSC technology, and CRISPR genome editing, as such, experience in these technologies is desirable although not required. Other duties will include participating in project planning, grant and manuscript writing, and the mentoring of more junior members of the laboratory. Lead investigators for this project are Drs. Xuezhong Liu MD, PhD, Susan Blanton, PhD, Katherina Walz, PhD, and Derek Dykxhoorn, PhD.

A successful candidate (Ph.D, M.D/Ph.D or MD) should have a strong background in molecular biology, animal or cell-based models of disease, genetics and genomics, and/or neuroscience. Experience in hearing loss or inner ear research would be beneficial but is not required.

Minimum Qualifications

Ph.D., M.D., or other doctoral-level degree in a related field of study. Possess a strong background in molecular biology, animal, or cell-based models of disease, genetics, and genomics, and/or neuroscience. Must be independent and highly motivated with strong communication and critical thinking skills, as well as a dedication to teamwork and collaboration.

UHealth-University of Miami Health System, South Florida~q~s only university-based health system, provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center, we are proud to serve South Florida, Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties, and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching, research and patient care. We~q~re the challenge you~q~ve been looking for.

Patient safety is a top priority. As a result, during the Influenza ("the flu") season (September through April), the University of Miami School of Medicine requires all employees who provide ongoing services to patients, work in a location (all Hospitals and clinics) where patient care is provided, or work in patient care or clinical care areas, to have an annual influenza vaccination. Failure to meet this requirement will result in rescinding or termination of employment.

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